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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

Overview of attention for article published in Molecular Cancer, August 2011
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter
wikipedia
19 Wikipedia pages

Citations

dimensions_citation
127 Dimensions

Readers on

mendeley
196 Mendeley
citeulike
1 CiteULike
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Title
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
Published in
Molecular Cancer, August 2011
DOI 10.1186/1476-4598-10-101
Pubmed ID
Authors

David P Minde, Zeinab Anvarian, Stefan GD Rüdiger, Madelon M Maurice

Abstract

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many questions remain as to how APC controls β-catenin degradation. Remarkably, the large C-terminal region of APC, which spans over 2000 amino acids and includes critical regions in downregulating β-catenin, is predicted to be natively unfolded. Here we discuss how this uncommonly large disordered region may help to coordinate the multiple cellular functions of APC. Recently, a significant number of germline and somatic missense mutations in the central region of APC were linked to tumorigenesis in the colon as well as extra-intestinal tissues. We classify and localize all currently known missense mutations in the APC structure. The molecular basis by which these mutations interfere with the function of APC remains unresolved. We propose several mechanisms by which cancer-related missense mutations in the large disordered domain of APC may interfere with tumor suppressor activity. Insight in the underlying molecular events will be invaluable in the development of novel strategies to counter dysregulated Wnt signaling by APC mutations in cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Netherlands 1 <1%
Austria 1 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Unknown 190 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 24%
Student > Bachelor 39 20%
Researcher 29 15%
Student > Master 26 13%
Other 10 5%
Other 26 13%
Unknown 19 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 32%
Biochemistry, Genetics and Molecular Biology 56 29%
Medicine and Dentistry 27 14%
Chemistry 7 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 16 8%
Unknown 22 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2023.
All research outputs
#6,487,475
of 23,002,898 outputs
Outputs from Molecular Cancer
#450
of 1,730 outputs
Outputs of similar age
#36,529
of 124,560 outputs
Outputs of similar age from Molecular Cancer
#10
of 18 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,730 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,560 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.