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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

Overview of attention for article published in Molecular Cancer, August 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
1 tweeter
wikipedia
16 Wikipedia pages

Citations

dimensions_citation
122 Dimensions

Readers on

mendeley
191 Mendeley
citeulike
1 CiteULike
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Title
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
Published in
Molecular Cancer, August 2011
DOI 10.1186/1476-4598-10-101
Pubmed ID
Authors

David P Minde, Zeinab Anvarian, Stefan GD Rüdiger, Madelon M Maurice

Abstract

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many questions remain as to how APC controls β-catenin degradation. Remarkably, the large C-terminal region of APC, which spans over 2000 amino acids and includes critical regions in downregulating β-catenin, is predicted to be natively unfolded. Here we discuss how this uncommonly large disordered region may help to coordinate the multiple cellular functions of APC. Recently, a significant number of germline and somatic missense mutations in the central region of APC were linked to tumorigenesis in the colon as well as extra-intestinal tissues. We classify and localize all currently known missense mutations in the APC structure. The molecular basis by which these mutations interfere with the function of APC remains unresolved. We propose several mechanisms by which cancer-related missense mutations in the large disordered domain of APC may interfere with tumor suppressor activity. Insight in the underlying molecular events will be invaluable in the development of novel strategies to counter dysregulated Wnt signaling by APC mutations in cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Netherlands 1 <1%
Austria 1 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Unknown 185 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 25%
Student > Bachelor 38 20%
Researcher 29 15%
Student > Master 24 13%
Other 10 5%
Other 25 13%
Unknown 18 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 33%
Biochemistry, Genetics and Molecular Biology 55 29%
Medicine and Dentistry 24 13%
Chemistry 7 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 16 8%
Unknown 21 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2022.
All research outputs
#5,963,293
of 21,380,143 outputs
Outputs from Molecular Cancer
#377
of 1,615 outputs
Outputs of similar age
#81,634
of 322,274 outputs
Outputs of similar age from Molecular Cancer
#4
of 12 outputs
Altmetric has tracked 21,380,143 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,615 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.