Title |
Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
|
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Published in |
BMC Genomic Data, November 2001
|
DOI | 10.1186/1471-2156-2-18 |
Pubmed ID | |
Authors |
Bo Chang, Richard S Smith, Maureen Peters, Olga V Savinova, Norman L Hawes, Adriana Zabaleta, Steven Nusinowitz, Janice E Martin, Muriel L Davisson, Constance L Cepko, Brigid LM Hogan, Simon WM John |
Abstract |
Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in most of these families are not identified and the affected developmental processes are poorly understood. Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma. |
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Geographical breakdown
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Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 27% |
Student > Ph. D. Student | 8 | 15% |
Professor | 8 | 15% |
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Other | 7 | 13% |
Unknown | 8 | 15% |
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Computer Science | 1 | 2% |
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