Title |
Alterations in PGC1α expression levels are involved in colorectal cancer risk: a qualitative systematic review
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Published in |
BMC Cancer, November 2017
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DOI | 10.1186/s12885-017-3725-3 |
Pubmed ID | |
Authors |
Jéssica Alonso-Molero, Carmen González-Donquiles, Tania Fernández-Villa, Fernanda de Souza-Teixeira, Laura Vilorio-Marqués, Antonio J. Molina, Vicente Martín |
Abstract |
Colorectal cancer (CRC) is a major global public health problem and the second leading cause of cancer-related death. Mitochondrial dysfunction has long been suspected to be involved in this type of tumorigenesis, as supported by an accumulating body of research evidence. However, little is known about how mitochondrial alterations contribute to tumorigenesis. Mitochondrial biogenesis is a fundamental cellular process required to maintain functional mitochondria and as an adaptive mechanism in response to changing energy requirements. Mitochondrial biogenesis is regulated by peroxisome proliferator-activated receptor gamma coactivator 1-α (PPARGC1A or PGC1α). In this paper, we report a systematic review to summarize current evidence on the role of PGC1α in the initiation and progression of CRC. The aim is to provide a basis for more comprehensive research. The literature search, data extraction and quality assessment were performed according to the document Guidance on the Conduct of Narrative Synthesis in Systematic Reviews and the PRISMA declaration. The studies included in this review aimed to evaluate whether increased or decreased PGC1α expression affects the development of CRC. Each article proposes a possible molecular mechanism of action and we create two concept maps. Our systematic review indicates that altered expression of PGC1α modifies CRC risk. Most studies showed that overexpression of this gene increases CRC risk, while some studies indicated that lower than normal expression levels could increase CRC risk. Thus, various authors propose PGC1α as a good candidate molecular target for cancer therapy. Reducing expression of this gene could help to reduce risk or progression of CRC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 17% |
Researcher | 3 | 13% |
Student > Ph. D. Student | 3 | 13% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 5 | 21% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 33% |
Medicine and Dentistry | 3 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Mathematics | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 25% |