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Mendeley readers
| Title |
Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids
|
|---|---|
| Published in |
Journal of Inflammation, July 2007
|
| DOI | 10.1186/1476-9255-4-15 |
| Pubmed ID | |
| Authors |
Lucia Rackova, Marek Oblozinsky, Daniela Kostalova, Viktor Kettmann, Lydia Bezakova |
| Abstract |
Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) alkaloids on activity of 12-lipoxygenase (12-LOX), was studied. The reactivity with 1,1-diphenyl-2-picryl-hydrazyl (DPPH), a free stable radical, was evaluated to elucidate the rate of possible lipid-derived radical scavenging in the mechanism of the enzyme inhibition.The results indicate that although the direct radical scavenging mechanism cannot be ruled out in the lipoxygenase inhibition by Mahonia aquifolium and its constituents, other mechanisms based on specific interaction between enzyme and alkaloids could play the critical role in the lipoxygenase inhibition rather than non-specific reactivity with free radicals. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 2 | 1% |
| India | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 144 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Researcher | 19 | 13% |
| Student > Doctoral Student | 14 | 9% |
| Student > Master | 13 | 9% |
| Student > Bachelor | 12 | 8% |
| Other | 23 | 16% |
| Unknown | 31 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 16% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Medicine and Dentistry | 16 | 11% |
| Chemistry | 12 | 8% |
| Other | 11 | 7% |
| Unknown | 34 | 23% |