Title |
The apelinergic system as an alternative to catecholamines in low-output septic shock
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Published in |
Critical Care, January 2018
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DOI | 10.1186/s13054-018-1942-z |
Pubmed ID | |
Authors |
David Coquerel, Xavier Sainsily, Lauralyne Dumont, Philippe Sarret, Éric Marsault, Mannix Auger-Messier, Olivier Lesur |
Abstract |
Catecholamines, in concert with fluid resuscitation, have long been recommended in the management of septic shock. However, not all patients respond positively and controversy surrounding the efficacy-to-safety profile of catecholamines has emerged, trending toward decatecholaminization. Contextually, it is time to re-examine the "maintaining blood pressure" paradigm by identifying safer and life-saving alternatives. We put in perspective the emerging and growing knowledge on a promising alternative avenue: the apelinergic system. This target exhibits invaluable pleiotropic properties, including inodilator activity, cardio-renal protection, and control of fluid homeostasis. Taken together, its effects are expected to be greatly beneficial for patients in septic shock. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 14% |
Japan | 3 | 7% |
United Kingdom | 3 | 7% |
Colombia | 2 | 5% |
Mexico | 1 | 2% |
Indonesia | 1 | 2% |
Ecuador | 1 | 2% |
Malaysia | 1 | 2% |
India | 1 | 2% |
Other | 3 | 7% |
Unknown | 21 | 49% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 36 | 84% |
Practitioners (doctors, other healthcare professionals) | 3 | 7% |
Scientists | 3 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 17% |
Student > Postgraduate | 5 | 11% |
Student > Bachelor | 4 | 9% |
Researcher | 4 | 9% |
Professor > Associate Professor | 4 | 9% |
Other | 14 | 30% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 48% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Neuroscience | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 3 | 7% |
Unknown | 10 | 22% |