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Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Overview of attention for article published in Malaria Journal, October 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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0 tweeters
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3 patents
wikipedia
7 Wikipedia pages

Citations

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88 Dimensions

Readers on

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111 Mendeley
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Title
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
Published in
Malaria Journal, October 2006
DOI 10.1186/1475-2875-5-84
Pubmed ID
Authors

Peter E Meissner, Germain Mandi, Boubacar Coulibaly, Steffen Witte, Théophile Tapsoba, Ulrich Mansmann, Jens Rengelshausen, Wolfgang Schiek, Albrecht Jahn, Ingeborg Walter-Sack, Gerd Mikus, Jürgen Burhenne, Klaus-Dieter Riedel, R Heiner Schirmer, Bocar Kouyaté, Olaf Müller

Abstract

The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa.

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Portugal 1 <1%
Switzerland 1 <1%
Unknown 107 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 14%
Student > Master 16 14%
Student > Ph. D. Student 12 11%
Student > Bachelor 12 11%
Other 11 10%
Other 25 23%
Unknown 19 17%
Readers by discipline Count As %
Medicine and Dentistry 23 21%
Chemistry 18 16%
Agricultural and Biological Sciences 15 14%
Biochemistry, Genetics and Molecular Biology 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 19 17%
Unknown 26 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2021.
All research outputs
#2,459,168
of 22,782,096 outputs
Outputs from Malaria Journal
#557
of 5,558 outputs
Outputs of similar age
#4,993
of 66,552 outputs
Outputs of similar age from Malaria Journal
#3
of 11 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,558 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,552 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.