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Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats

Overview of attention for article published in Nutrition & Metabolism, January 2018
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Title
Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats
Published in
Nutrition & Metabolism, January 2018
DOI 10.1186/s12986-018-0246-2
Pubmed ID
Authors

Mingyi Chen, Biyu Lu, Yuan Li, Yuanyuan Wang, Haihui Zheng, Danmin Zhong, Ziqiong Liao, Mengxia Wang, Fangli Ma, Qiongfeng Liao, Zhiyong Xie

Abstract

Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few studies have indicated that polysaccharides improve obesity by regulating the metabolism of the body. Therefore, a metabolomics approach, consisting of high resolution nuclear magnetic resonance (NMR) spectroscopy and a multivariate statistical technique, was applied to explore the mechanism of the protective effects of lentinan and Flos Lonicera polysaccharides (LF) on high-fat diet (HFD) induced obesity. In this study, rats were randomly divided into three groups: control diet (CD), HFD, and HFD supplemented with a mixture of lentinan and Flos Lonicera polysaccharide. Histopathological and clinical biochemical assessments were also conducted. A combination of a NMR metabolomics study and a multivariable statistical analysis method to distinguish urinary and fecal metabolites was applied. Significant obesity symptoms appeared in HFD rats (for example, significant weight gain, epididymal adipose accumulation and lipid deposition in hepatocytes), which was attenuated in the LF group. Additionally, the HFD induced a reduction of choline, citrate, pyruvate and glycerol and increased the levels of trimethylamine oxide (TMAO) and taurine. Of note, these metabolic disorders were reversed by LF intervention mainly through pathways of energy metabolism, choline metabolism and gut microbiota metabolism. LF supplementation had a re-balancing effect on the disturbed metabolic pathways in the obese body. The results of this study validate the therapeutic effect of the compound polysaccharide--LF in obesity and described the biochemical and metabolic mechanisms involved.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Ph. D. Student 8 18%
Student > Bachelor 6 14%
Researcher 5 11%
Student > Doctoral Student 3 7%
Other 3 7%
Unknown 10 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 20%
Biochemistry, Genetics and Molecular Biology 5 11%
Medicine and Dentistry 5 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Psychology 2 5%
Other 5 11%
Unknown 15 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2018.
All research outputs
#9,936,920
of 12,413,055 outputs
Outputs from Nutrition & Metabolism
#544
of 634 outputs
Outputs of similar age
#246,194
of 339,786 outputs
Outputs of similar age from Nutrition & Metabolism
#12
of 12 outputs
Altmetric has tracked 12,413,055 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 634 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.1. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.