Title |
Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data
|
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Published in |
BMC Genomics, July 2006
|
DOI | 10.1186/1471-2164-7-166 |
Pubmed ID | |
Authors |
Huixia Wang, Shuguang Huang, Jianyong Shou, Eric W Su, Jude E Onyia, Birong Liao, Shuyu Li |
Abstract |
NCI60 cell lines are derived from cancers of 9 tissue origins and have been invaluable in vitro models for cancer research and anti-cancer drug screen. Although extensive studies have been carried out to assess the molecular features of NCI60 cell lines related to cancer and their sensitivities to more than 100,000 chemical compounds, it remains unclear if and how well these cell lines represent or model their tumor tissues of origin. Identification and confirmation of correct origins of NCI60 cell lines are critical to their usage as model systems and to translate in vitro studies into clinical potentials. Here we report a direct comparison between NCI60 cell lines and primary tumors by analyzing global gene expression profiles. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
Belgium | 1 | 1% |
Unknown | 91 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 38% |
Student > Ph. D. Student | 12 | 13% |
Other | 9 | 9% |
Professor > Associate Professor | 7 | 7% |
Student > Bachelor | 5 | 5% |
Other | 13 | 14% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 35% |
Biochemistry, Genetics and Molecular Biology | 13 | 14% |
Medicine and Dentistry | 10 | 10% |
Engineering | 7 | 7% |
Computer Science | 5 | 5% |
Other | 11 | 11% |
Unknown | 16 | 17% |