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COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

Overview of attention for article published in Molecular Cancer, May 2008
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Title
COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro
Published in
Molecular Cancer, May 2008
DOI 10.1186/1476-4598-7-38
Pubmed ID
Authors

Huan-Ching Chuang, Adel Kardosh, Kevin J Gaffney, Nicos A Petasis, Axel H Schönthal

Abstract

An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2. We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC), inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC), has lost the ability to inhibit COX-2.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Netherlands 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 23%
Professor 5 11%
Student > Bachelor 5 11%
Researcher 5 11%
Student > Master 5 11%
Other 9 20%
Unknown 5 11%
Readers by discipline Count As %
Medicine and Dentistry 14 32%
Agricultural and Biological Sciences 10 23%
Chemistry 6 14%
Biochemistry, Genetics and Molecular Biology 4 9%
Social Sciences 1 2%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2024.
All research outputs
#7,452,489
of 22,783,848 outputs
Outputs from Molecular Cancer
#546
of 1,719 outputs
Outputs of similar age
#28,560
of 83,229 outputs
Outputs of similar age from Molecular Cancer
#3
of 5 outputs
Altmetric has tracked 22,783,848 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.