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Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control

Overview of attention for article published in BMC Gastroenterology, January 2018
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Title
Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control
Published in
BMC Gastroenterology, January 2018
DOI 10.1186/s12876-018-0751-9
Pubmed ID
Authors

Rita Moretti, Paola Caruso, Matteo Dal Ben, Silvia Gazzin, Claudio Tiribelli

Abstract

Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. These have shown variable success in case reports, with a presumably temporary effect, but with major side effects. We assessed the effects of oxcarbazepine treatment in 67 cases of cryoglobulinemia related neuropathy, who did not respond to either steroid or Gabapentin, or Pregabalin. Oxcarbazepine was chosen based on the promising preliminary results. Patients treated with Oxcarbazepine showed a rapid, discrete and persistent relief of polyneuropathic signs, without consistent side effects, and with a limited interaction with concomitant drugs. These data favor the use of oxcarbazepine as a useful tool in the management of neuropathic pain associated with Hepatitis-C cryoglobulin neuropathy.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 13%
Researcher 3 13%
Other 2 8%
Student > Bachelor 2 8%
Professor 2 8%
Other 3 13%
Unknown 9 38%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Neuroscience 3 13%
Nursing and Health Professions 2 8%
Psychology 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 2 8%
Unknown 8 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2023.
All research outputs
#20,031,563
of 25,483,400 outputs
Outputs from BMC Gastroenterology
#1,236
of 2,015 outputs
Outputs of similar age
#326,599
of 450,878 outputs
Outputs of similar age from BMC Gastroenterology
#22
of 33 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,015 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,878 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.