Title |
Modulation of neutrophil function by the tripeptide feG
|
---|---|
Published in |
BMC Immunology, March 2003
|
DOI | 10.1186/1471-2172-4-3 |
Pubmed ID | |
Authors |
Ronald D Mathison, A Dean Befus, Joseph S Davison, Richard C Woodman |
Abstract |
Neutrophils are critical in the defense against potentially harmful microorganisms, but their excessive and inappropriate activation can contribute significantly to tissue damage and a worsening pathology. Through the release of endocrine factors submandibular glands contribute to achieving a balance in neutrophil function by modulating the state of activation and migratory potential of circulating neutrophils. A putative hormonal candidate for these effects on neutrophils was identified as a heptapeptide named submandibular gland peptide T (SGP-T; sequence = TDIFEGG). Since the tripeptide FEG, derived from SGP-T, and its D-amino acid analogue feG had similar inhibitory effects on inflammatory reactions, we investigated the effects of feG on human and rat neutrophil function. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 30% |
Student > Master | 5 | 25% |
Researcher | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Professor > Associate Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 30% |
Medicine and Dentistry | 3 | 15% |
Immunology and Microbiology | 3 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Social Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |