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Targeting Gas6/TAM in cancer cells and tumor microenvironment

Overview of attention for article published in Molecular Cancer, January 2018
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)

Mentioned by

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2 tweeters
patent
2 patents

Citations

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64 Dimensions

Readers on

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109 Mendeley
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Title
Targeting Gas6/TAM in cancer cells and tumor microenvironment
Published in
Molecular Cancer, January 2018
DOI 10.1186/s12943-018-0769-1
Pubmed ID
Authors

Guiling Wu, Zhiqiang Ma, Yicheng Cheng, Wei Hu, Chao Deng, Shuai Jiang, Tian Li, Fulin Chen, Yang

Abstract

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM). In recent years, the roles of Gas6/TAM signalling in cancer cells and the tumour microenvironment have been studied, and some progress has made in targeted therapy, providing new potential directions for future investigations of cancer treatment. In this review, we introduce the Gas6 and TAM receptors and describe their involvement in different cancers and discuss the roles of Gas6 in cancer cells, the tumour microenvironment and metastasis. Finally, we introduce recent studies on Gas6/TAM targeting in cancer therapy, which will assist in the experimental design of future analyses and increase the potential use of Gas6 as a therapeutic target for cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 109 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 17%
Student > Master 17 16%
Student > Ph. D. Student 15 14%
Researcher 11 10%
Student > Doctoral Student 4 4%
Other 13 12%
Unknown 31 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 28%
Medicine and Dentistry 12 11%
Pharmacology, Toxicology and Pharmaceutical Science 12 11%
Agricultural and Biological Sciences 11 10%
Immunology and Microbiology 4 4%
Other 7 6%
Unknown 33 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2021.
All research outputs
#5,609,139
of 18,954,860 outputs
Outputs from Molecular Cancer
#316
of 1,436 outputs
Outputs of similar age
#125,136
of 383,706 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 18,954,860 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,436 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 383,706 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them