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Mendeley readers
Attention Score in Context
| Title |
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
|
|---|---|
| Published in |
Breast Cancer Research, September 2007
|
| DOI | 10.1186/bcr1769 |
| Pubmed ID | |
| Authors |
Thomas Schlange, Yutaka Matsuda, Susanne Lienhard, Alexandre Huber, Nancy E Hynes |
| Abstract |
De-regulation of the wingless and integration site growth factor (WNT) signaling pathway via mutations in APC and Axin, proteins that target beta-catenin for destruction, have been linked to various types of human cancer. These genetic alterations rarely, if ever, are observed in breast tumors. However, various lines of evidence suggest that WNT signaling may also be de-regulated in breast cancer. Most breast tumors show hypermethylation of the promoter region of secreted Frizzled-related protein 1 (sFRP1), a negative WNT pathway regulator, leading to downregulation of its expression. As a consequence, WNT signaling is enhanced and may contribute to proliferation of human breast tumor cells. We previously demonstrated that, in addition to the canonical WNT/beta-catenin pathway, WNT signaling activates the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in mouse mammary epithelial cells via epidermal growth factor receptor (EGFR) transactivation. |
Mendeley readers
The data shown below were compiled from readership statistics for 226 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| India | 2 | <1% |
| Chile | 1 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Spain | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 215 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 58 | 26% |
| Student > Ph. D. Student | 41 | 18% |
| Student > Bachelor | 33 | 15% |
| Student > Master | 20 | 9% |
| Student > Doctoral Student | 13 | 6% |
| Other | 39 | 17% |
| Unknown | 22 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 45% |
| Biochemistry, Genetics and Molecular Biology | 50 | 22% |
| Medicine and Dentistry | 24 | 11% |
| Chemistry | 5 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 15 | 7% |
| Unknown | 25 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2021.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Breast Cancer Research
#977
of 2,052 outputs
Outputs of similar age
#29,348
of 84,094 outputs
Outputs of similar age from Breast Cancer Research
#5
of 7 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.