Title |
The dual origin of the peripheral olfactory system: placode and neural crest
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Published in |
Molecular Brain, September 2011
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DOI | 10.1186/1756-6606-4-34 |
Pubmed ID | |
Authors |
Hiroyuki Katoh, Shinsuke Shibata, Kimiko Fukuda, Momoka Sato, Etsuko Satoh, Narihito Nagoshi, Takeo Minematsu, Yumi Matsuzaki, Chihiro Akazawa, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano |
Abstract |
The olfactory epithelium (OE) has a unique capacity for continuous neurogenesis, extending axons to the olfactory bulb with the assistance of olfactory ensheathing cells (OECs). The OE and OECs have been believed to develop solely from the olfactory placode, while the neural crest (NC) cells have been believed to contribute only the underlying structural elements of the olfactory system. In order to further elucidate the role of NC cells in olfactory development, we examined the olfactory system in the transgenic mice Wnt1-Cre/Floxed-EGFP and P0-Cre/Floxed-EGFP, in which migrating NC cells and its descendents permanently express GFP, and conducted transposon-mediated cell lineage tracing studies in chick embryos. |
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Mendeley readers
Geographical breakdown
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Psychology | 2 | 2% |
Other | 1 | 1% |
Unknown | 11 | 13% |