Title |
Myoblast fusion confusion: the resolution begins
|
---|---|
Published in |
Skeletal Muscle, January 2018
|
DOI | 10.1186/s13395-017-0149-3 |
Pubmed ID | |
Authors |
Srihari C. Sampath, Srinath C. Sampath, Douglas P. Millay |
Abstract |
The fusion of muscle precursor cells is a required event for proper skeletal muscle development and regeneration. Numerous proteins have been implicated to function in myoblast fusion; however, the majority are expressed in diverse tissues and regulate numerous cellular processes. How myoblast fusion is triggered and coordinated in a muscle-specific manner has remained a mystery for decades. Through the discovery of two muscle-specific fusion proteins, Myomaker and Myomerger-Minion, we are now primed to make significant advances in our knowledge of myoblast fusion. This article reviews the latest findings regarding the biology of Myomaker and Minion-Myomerger, places these findings in the context of known pathways in mammalian myoblast fusion, and highlights areas that require further investigation. As our understanding of myoblast fusion matures so does our potential ability to manipulate cell fusion for therapeutic purposes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 6 | 25% |
United States | 5 | 21% |
Brazil | 1 | 4% |
France | 1 | 4% |
Canada | 1 | 4% |
Norway | 1 | 4% |
Singapore | 1 | 4% |
Unknown | 8 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 63% |
Scientists | 7 | 29% |
Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 201 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 46 | 23% |
Student > Master | 30 | 15% |
Researcher | 25 | 12% |
Student > Bachelor | 20 | 10% |
Student > Postgraduate | 9 | 4% |
Other | 26 | 13% |
Unknown | 45 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 70 | 35% |
Agricultural and Biological Sciences | 34 | 17% |
Medicine and Dentistry | 10 | 5% |
Engineering | 8 | 4% |
Neuroscience | 6 | 3% |
Other | 23 | 11% |
Unknown | 50 | 25% |