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Surgical outcomes in patients with locally advanced gastric cancer treated with S-1 and oxaliplatin as neoadjuvant chemotherapy

Overview of attention for article published in World Journal of Surgical Oncology, January 2015
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Title
Surgical outcomes in patients with locally advanced gastric cancer treated with S-1 and oxaliplatin as neoadjuvant chemotherapy
Published in
World Journal of Surgical Oncology, January 2015
DOI 10.1186/s12957-015-0444-6
Pubmed ID
Authors

Daofu Feng, Meiha Leong, Ting Li, Lin Chen, Tao Li

Abstract

BackgroundWe wished to evaluate the impact of S-1 combined with oxaliplatin (SOX regimen) as neoadjuvant chemotherapy on surgical outcomes after gastrectomy with D2 lymphadenectomy.MethodsFrom February 2012 to September 2013, 170 patients with American Joint Committee on Cancer (AJCC) stage II¿III gastric cancer were assessed retrospectively. Eighty patients underwent neoadjuvant chemotherapy before radical gastrectomy, and 90 patients received surgical treatment with adjuvant chemotherapy. Patients received S-1 (80 mg/m2/day; days 1¿14) and oxaliplatin (130 mg/m2; day 1) as neoadjuvant or adjuvant chemotherapy, and this schedule was repeated every 3 weeks. Gastrectomy with D2 lymphadenectomy was standard therapy for each patient. Surgical outcomes between the two groups were analyzed statistically.ResultsThere was no significant difference in the total prevalence of complications between neoadjuvant and adjuvant groups (18.8% vs. 22.2%, P¿=¿0.704). The most common postoperative complications were surgical site infection (6.5%) and gastrointestinal motility disorders (3.5%). The clinical response rate was 68.8%, and ten patients (12.5%) had a pathological complete response after neoadjuvant chemotherapy. The SOX regimen as neoadjuvant chemotherapy for AJCC stage II/III gastric cancer can be effective without increasing the risk of postoperative complications.ConclusionsThe SOX regimen could be a neoadjuvant chemotherapy for advanced gastric cancer worldwide in the future.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 13%
Student > Bachelor 4 13%
Student > Ph. D. Student 4 13%
Lecturer > Senior Lecturer 3 9%
Student > Master 3 9%
Other 6 19%
Unknown 8 25%
Readers by discipline Count As %
Medicine and Dentistry 17 53%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 1 3%
Unknown 10 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2015.
All research outputs
#20,254,575
of 22,783,848 outputs
Outputs from World Journal of Surgical Oncology
#1,583
of 2,042 outputs
Outputs of similar age
#296,975
of 353,050 outputs
Outputs of similar age from World Journal of Surgical Oncology
#148
of 158 outputs
Altmetric has tracked 22,783,848 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,042 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 158 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.