Title |
Composition and biological significance of the human Nα-terminal acetyltransferases
|
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Published in |
BMC Proceedings, August 2009
|
DOI | 10.1186/1753-6561-3-s6-s3 |
Pubmed ID | |
Authors |
Kristian K Starheim, Darina Gromyko, Rolf Velde, Jan Erik Varhaug, Thomas Arnesen |
Abstract |
Protein Nalpha-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links Nalpha-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, Nalpha-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of Nalpha-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on Nalpha-terminal acetylation in humans and other higher eukaryotes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 3 | 5% |
Unknown | 55 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 21% |
Student > Ph. D. Student | 11 | 19% |
Student > Master | 9 | 16% |
Student > Bachelor | 6 | 10% |
Professor > Associate Professor | 4 | 7% |
Other | 10 | 17% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 57% |
Biochemistry, Genetics and Molecular Biology | 12 | 21% |
Medicine and Dentistry | 4 | 7% |
Computer Science | 1 | 2% |
Neuroscience | 1 | 2% |
Other | 1 | 2% |
Unknown | 6 | 10% |