Title |
Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin
|
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Published in |
Microbial Cell Factories, April 2011
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DOI | 10.1186/1475-2859-10-29 |
Pubmed ID | |
Authors |
Karin Lemuth, Kristin Steuer, Christoph Albermann |
Abstract |
The xanthophyll astaxanthin is a high-value compound with applications in the nutraceutical, cosmetic, food, and animal feed industries. Besides chemical synthesis and extraction from naturally producing organisms like Haematococcus pluvialis, heterologous biosynthesis in non-carotenogenic microorganisms like Escherichia coli, is a promising alternative for sustainable production of natural astaxanthin. Recent achievements in the metabolic engineering of E. coli strains have led to a significant increase in the productivity of carotenoids like lycopene or β-carotene by increasing the metabolic flux towards the isoprenoid precursors. For the heterologous biosynthesis of astaxanthin in E. coli, however, the conversion of β-carotene to astaxanthin is obviously the most critical step towards an efficient biosynthesis of astaxanthin. |
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