Title |
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
|
---|---|
Published in |
BMC Cancer, January 2012
|
DOI | 10.1186/1471-2407-12-21 |
Pubmed ID | |
Authors |
Ingrid Moen, Charlotte Jevne, Jian Wang, Karl-Henning Kalland, Martha Chekenya, Lars A Akslen, Linda Sleire, Per Ø Enger, Rolf K Reed, Anne M Øyan, Linda EB Stuhr |
Abstract |
The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene expression. Secondly, since tumor hypoxia influences several aspects of tumor pathophysiology, we hypothesized that hyperoxia might have an inhibitory effect on tumor growth per se. Finally, we aimed to identify differences in gene expression and key molecular mechanisms, both in the native state and following treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 67 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 20% |
Student > Ph. D. Student | 9 | 13% |
Researcher | 8 | 12% |
Student > Master | 6 | 9% |
Professor > Associate Professor | 5 | 7% |
Other | 14 | 20% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 20% |
Medicine and Dentistry | 12 | 17% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Physics and Astronomy | 4 | 6% |
Engineering | 3 | 4% |
Other | 7 | 10% |
Unknown | 17 | 25% |