Title |
Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
|
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Published in |
Genome Biology, February 2004
|
DOI | 10.1186/gb-2004-5-2-209 |
Pubmed ID | |
Authors |
Liam P Keegan, Anne Leroy, Duncan Sproul, Mary A O'Connell |
Abstract |
Adenosine deaminases acting on RNA (ADARs) were discovered as a result of their ability extensively to deaminate adenosines in any long double-stranded RNA, converting them to inosines. Subsequently, ADARs were found to deaminate adenosines site-specifically within the coding sequences of transcripts encoding ion-channel subunits, increasing the diversity of these proteins in the central nervous system. ADARI is now known to be involved in defending the genome against viruses, and it may affect RNA interference. ADARs are found in animals but are not known in other organisms. It appears that ADARs evolved from a member of another family, adenosine deaminases acting on tRNAs (ADATs), by steps including fusion of two or more double-stranded-RNA binding domains to a common type of zinc-containing adenosine-deaminase domain. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 121 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 23% |
Researcher | 16 | 13% |
Student > Master | 14 | 11% |
Student > Bachelor | 11 | 9% |
Student > Doctoral Student | 8 | 6% |
Other | 22 | 18% |
Unknown | 25 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 43 | 34% |
Biochemistry, Genetics and Molecular Biology | 38 | 30% |
Immunology and Microbiology | 4 | 3% |
Medicine and Dentistry | 4 | 3% |
Engineering | 3 | 2% |
Other | 7 | 6% |
Unknown | 26 | 21% |