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TRIM5α selectively binds a restriction-sensitive retroviral capsid

Overview of attention for article published in Retrovirology, June 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

2 blogs
3 Wikipedia pages


205 Dimensions

Readers on

92 Mendeley
2 CiteULike
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TRIM5α selectively binds a restriction-sensitive retroviral capsid
Published in
Retrovirology, June 2005
DOI 10.1186/1742-4690-2-40
Pubmed ID

Sarah Sebastian, Jeremy Luban


TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5alpha binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 1%
South Africa 1 1%
Brazil 1 1%
Unknown 87 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 28%
Researcher 17 18%
Student > Bachelor 16 17%
Student > Master 13 14%
Student > Doctoral Student 3 3%
Other 8 9%
Unknown 9 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 40%
Biochemistry, Genetics and Molecular Biology 24 26%
Immunology and Microbiology 7 8%
Medicine and Dentistry 7 8%
Chemistry 2 2%
Other 2 2%
Unknown 13 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2021.
All research outputs
of 21,338,376 outputs
Outputs from Retrovirology
of 1,029 outputs
Outputs of similar age
of 321,992 outputs
Outputs of similar age from Retrovirology
of 1 outputs
Altmetric has tracked 21,338,376 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,029 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them