Arenavirus infection correlates with lower survival of its natural rodent host in a long-term capture-mark-recapture study

Joachim Mariën, Vincent Sluydts, Benny Borremans, Sophie Gryseels, Bram Vanden Broecke, Christopher A. Sabuni, Abdul A. S. Katakweba, Loth S. Mulungu, Stephan Günther, Joëlle Goüy de Bellocq, Apia W. Massawe, Herwig Leirs

Parasite evolution is hypothesized to select for levels of parasite virulence that maximise transmission success. When host population densities fluctuate, low levels of virulence with limited impact on the host are expected, as this should increase the likelihood of surviving periods of low host density. We examined the effects of Morogoro arenavirus on the survival and recapture probability of multimammate mice (Mastomys natalensis) using a seven-year capture-mark-recapture time series. Mastomys natalensis is the natural host of Morogoro virus and is known for its strong seasonal density fluctuations. Antibody presence was negatively correlated with survival probability (effect size: 5-8% per month depending on season) but positively with recapture probability (effect size: 8%). The small negative correlation between host survival probability and antibody presence suggests that either the virus has a negative effect on host condition, or that hosts with lower survival probability are more likely to obtain Morogoro virus infection, for example due to particular behavioural or immunological traits. The latter hypothesis is supported by the positive correlation between antibody status and recapture probability which suggests that risky behaviour might increase the probability of becoming infected.