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Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

Overview of attention for article published in BMC Cancer, August 2010
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Citations

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Title
Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells
Published in
BMC Cancer, August 2010
DOI 10.1186/1471-2407-10-414
Pubmed ID
Authors

Masahiro Uchino, Hiroko Kojima, Kenta Wada, Mika Imada, Fumitoshi Onoda, Hiroyuki Satofuka, Takahiko Utsugi, Yasufumi Murakami

Abstract

In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype. However, the MCF-7 cell line, which has a luminal epithelial-like phenotype and lacks a CD44+/CD24- subpopulation, has rare cell populations with higher Matrigel invasive ability. Thus, what are the potentially important differences between invasive and non-invasive breast cancer cells, and are the differences related to EMT or CD44/CD24 expression?

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 1%
United States 1 <1%
Portugal 1 <1%
Germany 1 <1%
Unknown 129 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 25%
Researcher 22 16%
Student > Master 15 11%
Student > Bachelor 13 10%
Student > Doctoral Student 12 9%
Other 20 15%
Unknown 18 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 30%
Biochemistry, Genetics and Molecular Biology 31 23%
Medicine and Dentistry 26 19%
Engineering 6 4%
Nursing and Health Professions 1 <1%
Other 10 7%
Unknown 20 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2015.
All research outputs
#15,319,634
of 22,785,242 outputs
Outputs from BMC Cancer
#4,103
of 8,289 outputs
Outputs of similar age
#76,344
of 94,519 outputs
Outputs of similar age from BMC Cancer
#33
of 44 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,289 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,519 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.