Title |
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
|
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Published in |
Breast Cancer Research, August 2004
|
DOI | 10.1186/bcr920 |
Pubmed ID | |
Authors |
Gabriela Dontu, Kyle W Jackson, Erin McNicholas, Mari J Kawamura, Wissam M Abdallah, Max S Wicha |
Abstract |
Notch signaling has been implicated in the regulation of cell-fate decisions such as self-renewal of adult stem cells and differentiation of progenitor cells along a particular lineage. Moreover, depending on the cellular and developmental context, the Notch pathway acts as a regulator of cell survival and cell proliferation. Abnormal expression of Notch receptors has been found in different types of epithelial metaplastic lesions and neoplastic lesions, suggesting that Notch may act as a proto-oncogene. The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 1% |
Canada | 3 | <1% |
Spain | 2 | <1% |
United States | 2 | <1% |
Portugal | 2 | <1% |
Italy | 1 | <1% |
Greece | 1 | <1% |
India | 1 | <1% |
Unknown | 370 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 105 | 27% |
Researcher | 63 | 16% |
Student > Master | 55 | 14% |
Student > Bachelor | 32 | 8% |
Professor > Associate Professor | 23 | 6% |
Other | 54 | 14% |
Unknown | 54 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 148 | 38% |
Biochemistry, Genetics and Molecular Biology | 72 | 19% |
Medicine and Dentistry | 54 | 14% |
Engineering | 11 | 3% |
Chemistry | 6 | 2% |
Other | 28 | 7% |
Unknown | 67 | 17% |