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Mendeley readers
Attention Score in Context
| Title |
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium
|
|---|---|
| Published in |
Journal of Circadian Rhythms, February 2007
|
| DOI | 10.1186/1740-3391-5-3 |
| Pubmed ID | |
| Authors |
Sevag A Kaladchibachi, Brad Doble, Norman Anthopoulos, James R Woodgett, Armen S Manoukian |
| Abstract |
Bipolar disorder (BPD) is a widespread condition characterized by recurring states of mania and depression. Lithium, a direct inhibitor of glycogen synthase kinase 3 (GSK3) activity, and a mainstay in BPD therapeutics, has been proposed to target GSK3 as a mechanism of mood stabilization. In addition to mood imbalances, patients with BPD often suffer from circadian disturbances. GSK3, an essential kinase with widespread roles in development, cell survival, and metabolism has been demonstrated to be an essential component of the Drosophila circadian clock. We sought to investigate the role of GSK3 in the mammalian clock mechanism, as a possible mediator of lithium's therapeutic effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 103 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 17% |
| Student > Master | 17 | 16% |
| Professor | 14 | 13% |
| Researcher | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Other | 21 | 19% |
| Unknown | 12 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 29% |
| Medicine and Dentistry | 22 | 20% |
| Neuroscience | 14 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Psychology | 4 | 4% |
| Other | 10 | 9% |
| Unknown | 20 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2020.
All research outputs
#4,695,994
of 22,785,242 outputs
Outputs from Journal of Circadian Rhythms
#28
of 103 outputs
Outputs of similar age
#22,440
of 162,068 outputs
Outputs of similar age from Journal of Circadian Rhythms
#2
of 3 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.