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The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury

Overview of attention for article published in Fluids and Barriers of the CNS, March 2017
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Title
The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury
Published in
Fluids and Barriers of the CNS, March 2017
DOI 10.1186/s12987-017-0056-3
Pubmed ID
Authors

Jianming Xiang, Lisa J. Routhe, D. Andrew Wilkinson, Ya Hua, Torben Moos, Guohua Xi, Richard F. Keep

Abstract

While the impact of hemorrhagic and ischemic strokes on the blood-brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has received much less attention. The purpose of this review is to examine evidence of choroid plexus injury in clinical and preclinical studies of intraventricular hemorrhage, subarachnoid hemorrhage, intracerebral hemorrhage and ischemic stroke. It then discusses evidence that the choroid plexuses are important in the response to brain injury, with potential roles in limiting damage. The overall aim of the review is to highlight deficiencies in our knowledge on the impact of hemorrhagic and ischemic strokes on the choroid plexus, particularly with reference to intraventricular hemorrhage, and to suggest that a greater understanding of the response of the choroid plexus to stroke may open new avenues for brain protection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 31%
Researcher 7 9%
Student > Master 7 9%
Professor 5 7%
Other 5 7%
Other 13 18%
Unknown 14 19%
Readers by discipline Count As %
Medicine and Dentistry 16 22%
Neuroscience 16 22%
Agricultural and Biological Sciences 10 14%
Biochemistry, Genetics and Molecular Biology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 9%
Unknown 17 23%