Title |
An improved ontological representation of dendritic cells as a paradigm for all cell types
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Published in |
BMC Bioinformatics, February 2009
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DOI | 10.1186/1471-2105-10-70 |
Pubmed ID | |
Authors |
Anna Maria Masci, Cecilia N Arighi, Alexander D Diehl, Anne E Lieberman, Chris Mungall, Richard H Scheuermann, Barry Smith, Lindsay G Cowell |
Abstract |
Recent increases in the volume and diversity of life science data and information and an increasing emphasis on data sharing and interoperability have resulted in the creation of a large number of biological ontologies, including the Cell Ontology (CL), designed to provide a standardized representation of cell types for data annotation. Ontologies have been shown to have significant benefits for computational analyses of large data sets and for automated reasoning applications, leading to organized attempts to improve the structure and formal rigor of ontologies to better support computation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL's utility for computation and for cross-species data integration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 7% |
Spain | 1 | 2% |
United Kingdom | 1 | 2% |
Unknown | 41 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 39% |
Student > Ph. D. Student | 7 | 15% |
Other | 4 | 9% |
Student > Doctoral Student | 2 | 4% |
Professor | 2 | 4% |
Other | 7 | 15% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 37% |
Medicine and Dentistry | 7 | 15% |
Computer Science | 4 | 9% |
Immunology and Microbiology | 4 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Other | 4 | 9% |
Unknown | 7 | 15% |