Title |
Viral hepatitis and hepatocellular carcinoma
|
---|---|
Published in |
World Journal of Surgical Oncology, May 2005
|
DOI | 10.1186/1477-7819-3-27 |
Pubmed ID | |
Authors |
Peter P Michielsen, Sven M Francque, Jurgen L van Dongen |
Abstract |
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The incidence of HCC varies considerably with the geographic area because of differences in the major causative factors. Chronic hepatitis B and C, mostly in the cirrhotic stage, are responsible for the great majority of cases of HCC worldwide. The geographic areas at the highest risk are South-East Asia and sub-Saharan Africa, here hepatitis B is highly endemic and is the main cause of HCC. In areas with an intermediate rate of HCC such as Southern Europe and Japan, hepatitis C is the predominant cause, whereas in low rate areas such as Northern Europe and the USA, HCC is often related to other factors as alcoholic liver disease. There is a rising incidence in HCC in developed countries during the last two decades, due to the increasing rate of hepatitis C infection and improvement of the clinical management of cirrhosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 1% |
Mexico | 1 | 1% |
Germany | 1 | 1% |
Unknown | 84 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 16% |
Student > Master | 14 | 16% |
Student > Ph. D. Student | 7 | 8% |
Student > Postgraduate | 5 | 6% |
Student > Bachelor | 4 | 5% |
Other | 14 | 16% |
Unknown | 29 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 36% |
Agricultural and Biological Sciences | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Nursing and Health Professions | 3 | 3% |
Social Sciences | 2 | 2% |
Other | 6 | 7% |
Unknown | 29 | 33% |