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Attention Score in Context
| Title |
Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study
|
|---|---|
| Published in |
Orphanet Journal of Rare Diseases, February 2015
|
| DOI | 10.1186/s13023-015-0230-0 |
| Pubmed ID | |
| Authors |
Angelo Valerio Marzano, Valentina Trevisan, Elisa Cairoli, Cristina Eller-Vainicher, Valentina Morelli, Anna Spada, Carlo Crosti, Iacopo Chiodini |
| Abstract |
BackgroundThe presence of hypovitaminosis D in patients with autoimmune bullous skin diseases, such as pemphigus vulgaris (PV) and bullous pemphigoid (BP), is debated. In a previous study we found an increased prevalence of vertebral fractures (VFx) and hypovitaminosis D in PV and BP patients. The present study extends the sample size of the previous one, for investigating the 25-hydroxyvitamin D (25OHVitD) levels in relation with the skeletal health and disease intensity in these patients.MethodsThe previous study was performed in 13 PV and 15 BP patients and 28 controls. Data from 39 additional patients (22 PV and 17 BP) were now added. Eventually, we studied 67 patients (35 PV, 32 BP, 51 females), aged 64.7¿±¿16.9 years and 67 age- gender- and body mass index-matched controls. In all subjects, serum 25OHVitD, calcium and alkaline phosphatase (ALP) levels were measured, bone mineral density (BMD) was evaluated by Dual-energy X-ray. Absorptiometry at lumbar spine (LS) and femoral neck (FN) and the presence of VFx were ascertained by visual assessment from spinal radiographs. In patients, the disease intensity was evaluated by the autoimmune bullous skin disorder intensity score (ABSIS).ResultsAs compared with controls, both PV and BP patients showed lower 25OHVitD (22.2¿±¿11.1 vs 13.9¿±¿8.3 ng/mL, p¿<¿0.001 and 22.4¿±¿14.9 vs 9.5¿±¿7.7 ng/mL, p¿<¿0.0001, respectively) and higher prevalence of severe hypovitaminosis D (22.9 vs 48.6%, p¿<¿0.02 and 31.1 vs 75.0%, p¿<¿0.0001, respectively) and VFx (28.6 vs 57.1%, p¿=¿0.03 and 34.4 vs 62.5%, P¿=¿0.02, respectively). In both PV and BP patients, LS and FN BMD did not differ from controls. In the whole patients¿ group, ABSIS score was inversely associated with 25OHVitD levels (R¿=¿¿0.36, p¿<¿0.005), regardless of age (ß¿=¿¿3.2, P¿=¿0.009).ConclusionsPV and BP patients have an increased prevalence of hypovitaminosis D and VFx. The extended study shows, for the first time, that the 25OHVitD levels are inversely associated with disease intensity and that VFx occur in spite of a not reduced BMD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 38 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 15% |
| Student > Bachelor | 5 | 13% |
| Other | 4 | 10% |
| Student > Ph. D. Student | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 13 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 44% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Unspecified | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 15 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2015.
All research outputs
#20,255,902
of 22,785,242 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,458
of 2,614 outputs
Outputs of similar age
#296,442
of 352,352 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#48
of 53 outputs
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