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Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified

Overview of attention for article published in BMC Molecular and Cell Biology, October 2003
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2 patents

Citations

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10 Mendeley
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Title
Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified
Published in
BMC Molecular and Cell Biology, October 2003
DOI 10.1186/1471-2091-4-14
Pubmed ID
Authors

Jesse J Guidry, Frank Shewmaker, Karol Maskos, Samuel Landry, Pernilla Wittung-Stafshede

Abstract

The co-chaperonin protein 10 (cpn10) assists cpn60 in the folding of nonnative polypeptides in a wide range of organisms. All known cpn10 molecules are heptamers of seven identical subunits that are linked together by beta-strand interactions at a large and flexible interface. Unfolding of human mitochondrial cpn10 in urea results in an unfolded heptameric state whereas GuHCl additions result in unfolded monomers. To address the role of specific interface residues in the assembly of cpn10 we prepared two point-mutated variants, in each case removing a hydrophobic residue positioned at the subunit-subunit interface.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 20%
Librarian 1 10%
Lecturer 1 10%
Student > Ph. D. Student 1 10%
Student > Bachelor 1 10%
Other 2 20%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 20%
Medicine and Dentistry 2 20%
Agricultural and Biological Sciences 2 20%
Business, Management and Accounting 1 10%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2013.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#19,782
of 56,293 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#1
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,293 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them