Title |
Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients
|
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Published in |
European Journal of Medical Research, February 2012
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DOI | 10.1186/2047-783x-17-4 |
Pubmed ID | |
Authors |
Peter Arne Gerber, Stephan Meller, Tatiana Eames, Bettina Alexandra Buhren, Holger Schrumpf, Sonja Hetzer, Laura Maximiliane Ehmann, Wilfried Budach, Edwin Bölke, Christiane Matuschek, Andreas Wollenberg, Bernhard Homey |
Abstract |
In recent years inhibitors directed against the epidermal growth factor receptor (EGFR) have evolved as effective targeting cancer drugs. Characteristic papulopustular exanthemas, often described as acneiform rashes, are the most frequent adverse effect associated with this class of novel cancer drugs and develop in > 90% of patients. Notably, the rash may significantly compromise the patients' quality of life, thereby potentially leading to incompliance as well as dose reduction or even termination of the anti-EGFR therapy. Yet, an effective dermatologic management of cutaneous adverse effects can be achieved. Whereas various case reports, case series or expert opinions on the management of EGFR-inhibitor (EGFRI) induced rashes have been published, data on systematic management studies are sparse. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 22% |
Student > Ph. D. Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Other | 9 | 24% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 38% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Nursing and Health Professions | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Chemistry | 3 | 8% |
Other | 5 | 14% |
Unknown | 4 | 11% |