Title |
Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population
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Published in |
BMC Genomic Data, February 2015
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DOI | 10.1186/s12863-015-0172-5 |
Pubmed ID | |
Authors |
Huan Chen, Junquan Xu, Yuxi Zhou, Yong Gao, Guoqing Wang, Jiguang Xia, Michael SY Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan, Yimin Sun |
Abstract |
BackgroundDyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis.ResultsThe study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering GNPTAB, GNPTG and NAGPA were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB and rs882294 in NAGPA with developmental dyslexia was identified after FDR correction for multiple comparisons.ConclusionOur results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population. |
X Demographics
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Student > Bachelor | 4 | 8% |
Student > Doctoral Student | 4 | 8% |
Other | 9 | 17% |
Unknown | 15 | 29% |
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Psychology | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
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Neuroscience | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Other | 9 | 17% |
Unknown | 18 | 35% |