Title |
Non-viral gene delivery systems for tissue repair and regeneration
|
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Published in |
Journal of Translational Medicine, February 2018
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DOI | 10.1186/s12967-018-1402-1 |
Pubmed ID | |
Authors |
Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang, Chunmao Han |
Abstract |
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity. However, there is no ideal nVGDS for TRR, hence, there is widespread research to improve their properties. This review introduces the basic principles and key aspects of commonly-used nVGDSs. We focus on recent advances in their applications, current challenges, and future directions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 176 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 18% |
Student > Master | 24 | 14% |
Researcher | 18 | 10% |
Student > Bachelor | 11 | 6% |
Other | 9 | 5% |
Other | 17 | 10% |
Unknown | 65 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 29 | 16% |
Chemistry | 14 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 6% |
Materials Science | 10 | 6% |
Medicine and Dentistry | 10 | 6% |
Other | 30 | 17% |
Unknown | 72 | 41% |