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Characterisation of recent foot-and-mouth disease viruses from African buffalo (Syncerus caffer) and cattle in Kenya is consistent with independent virus populations

Overview of attention for article published in BMC Veterinary Research, February 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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8 tweeters

Citations

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16 Dimensions

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91 Mendeley
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Title
Characterisation of recent foot-and-mouth disease viruses from African buffalo (Syncerus caffer) and cattle in Kenya is consistent with independent virus populations
Published in
BMC Veterinary Research, February 2015
DOI 10.1186/s12917-015-0333-9
Pubmed ID
Authors

Sabenzia Nabalayo Wekesa, Abraham Kiprotich Sangula, Graham J Belsham, Kirsten Tjornehoj, Vincent B Muwanika, Francis Gakuya, Dominic Mijele, Hans Redlef Siegismund

Abstract

BackgroundUnderstanding the epidemiology of foot-and-mouth disease (FMD), including roles played by different hosts, is essential for improving disease control. The African buffalo (Syncerus caffer) is a reservoir for the SAT serotypes of FMD virus (FMDV). Large buffalo populations commonly intermingle with livestock in Kenya, yet earlier studies have focused on FMD in the domestic livestock, hence the contribution of buffalo to disease in livestock is largely unknown. This study analysed 47 epithelia collected from FMD outbreaks in Kenyan cattle between 2008 and 2012, and 102 probang and serum samples collected from buffalo in three different Kenyan ecosystems; Maasai-Mara (MME) (n¿=¿40), Tsavo (TSE) (n¿=¿33), and Meru (ME) (n¿=¿29).ResultsAntibodies against FMDV non-structural proteins were found in 65 of 102 (64%) sera from buffalo with 44/102 and 53/102 also having neutralising antibodies directed against FMDV SAT 1 and SAT 2, respectively. FMDV RNA was detected in 42% of the buffalo probang samples by RT-qPCR (Cycle Threshold (Ct) ¿32). Two buffalo probang samples were positive by VI and were identified as FMDV SAT 1 and SAT 2 by Ag-ELISA, while the latter assay detected serotypes O (1), A (20), SAT 1 (7) and SAT 2 (19) in the 47 cattle epithelia. VP1 coding sequences were generated for two buffalo and 21 cattle samples. Phylogenetic analyses revealed SAT 1 and SAT 2 virus lineages within buffalo that were distinct from those detected in cattle.ConclusionsWe found that FMDV serotypes O, A, SAT 1 and SAT 2 were circulating among cattle in Kenya and cause disease, but only SAT 1 and SAT 2 viruses were successfully isolated from clinically normal buffalo. The buffalo isolates were genetically distinct from isolates obtained from cattle. Control efforts should focus primarily on reducing FMDV circulation among livestock and limiting interaction with buffalo. Comprehensive studies incorporating additional buffalo viruses are recommended.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Algeria 1 1%
Unknown 89 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 21%
Researcher 15 16%
Student > Ph. D. Student 15 16%
Lecturer 4 4%
Other 4 4%
Other 16 18%
Unknown 18 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 30%
Veterinary Science and Veterinary Medicine 17 19%
Environmental Science 7 8%
Biochemistry, Genetics and Molecular Biology 7 8%
Medicine and Dentistry 5 5%
Other 9 10%
Unknown 19 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2015.
All research outputs
#4,018,940
of 15,265,759 outputs
Outputs from BMC Veterinary Research
#273
of 2,241 outputs
Outputs of similar age
#68,659
of 286,052 outputs
Outputs of similar age from BMC Veterinary Research
#11
of 50 outputs
Altmetric has tracked 15,265,759 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,241 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.