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Cost effective assay choice for rare disease study designs

Overview of attention for article published in Orphanet Journal of Rare Diseases, February 2015
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Title
Cost effective assay choice for rare disease study designs
Published in
Orphanet Journal of Rare Diseases, February 2015
DOI 10.1186/s13023-015-0226-9
Pubmed ID
Authors

Desmond D Campbell, Robert M Porsch, Stacey S Cherny, Valeria Capra, Elisa Merello, Patrizia De Marco, Pak C Sham, Maria-Mercè Garcia-Barceló

Abstract

High throughput assays tend to be expensive per subject. Often studies are limited not so much by the number of subjects available as by assay costs, making assay choice a critical issue. We have developed a framework for assay choice that maximises the number of true disease causing mechanisms `seen¿, given limited resources. Although straightforward, some of the ramifications of our methodology run counter to received wisdom on study design. We illustrate our methodology with examples, and have built a website allowing calculation of quantities of interest to those designing rare disease studies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 26%
Researcher 4 17%
Professor > Associate Professor 3 13%
Professor 2 9%
Student > Ph. D. Student 2 9%
Other 5 22%
Unknown 1 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 30%
Medicine and Dentistry 6 26%
Nursing and Health Professions 2 9%
Agricultural and Biological Sciences 2 9%
Mathematics 1 4%
Other 4 17%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2015.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,289
of 3,105 outputs
Outputs of similar age
#254,031
of 360,581 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#27
of 37 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,105 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.