BackgroundParents caring for a child with Cystic Fibrosis (CF) are at high risk for psychological distress and have limited access to psychological care. Therefore, a web-based psychological support program for severely distressed parents of children with CF (WEP-CARE) was developed and evaluated for its feasibility and efficacy.MethodsA clinical expert panel developed WEP-CARE based on principles of cognitive-behavioral therapy. This web-based writing therapy comprises nine sessions, tailored for the specific needs of caregivers. The pilot study was conducted as a single-group intervention with pre-post-follow-up design. Out of 31 participants, 23 parents completed the intervention (21 female; mean age 37 years; SD¿=¿6.2 years, range 25 ¿ 48 years). Psychological symptoms and quality of life were assessed online by self-report measures at pre and post treatment and followed up 3 month later.ResultsOn average, the caregivers¿ symptoms of anxiety decreased statistically significant and clinical relevant about five points from an elevated (M¿=¿11.4; SD =2.6) to a normal level (M¿=¿6.7; SD¿=¿2.6; p¿<¿0.001) between pre and post treatment. Fear of disease progression (p¿<¿0.001) and symptoms of depression (p¿=¿0.02) significantly decreased as well. Quality of life significantly improved (p¿=¿0.01). The effects were maintained at the 3-months follow-up assessment.ConclusionsWEP-CARE is feasible and promising regarding its efficacy to improve parental mental health and quality of life.