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Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins

Overview of attention for article published in BMC Neuroscience, January 2006
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4 Wikipedia pages

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63 Mendeley
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Title
Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins
Published in
BMC Neuroscience, January 2006
DOI 10.1186/1471-2202-7-1
Pubmed ID
Authors

Paul J Kammermeier

Abstract

Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I mGluR function and distribution. Constitutively expressed 'long' Homer proteins (Homer 1b, 1c, 2 and 3) induce dendritic localization of group I mGluRs and receptor clustering, either internally or on the plasma membrane. Short Homer proteins (Homer 1a, Ania-3) exhibit regulated expression and act as dominant negatives, producing effects on mGluR distribution and function that oppose those of the long Homer proteins. There remains some controversy over whether long Homer proteins induce receptor internalization by inducing retention in the endoplasmic reticulum, or induce mGluR clustering on the plasma membrane. Further, an exhaustive study of the effects of each long Homer isoform on mGluR distribution has not been published.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 5%
Spain 2 3%
Canada 1 2%
Unknown 57 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 29%
Researcher 14 22%
Student > Master 9 14%
Professor > Associate Professor 4 6%
Student > Doctoral Student 3 5%
Other 5 8%
Unknown 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 38%
Neuroscience 11 17%
Medicine and Dentistry 10 16%
Biochemistry, Genetics and Molecular Biology 3 5%
Psychology 2 3%
Other 3 5%
Unknown 10 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2023.
All research outputs
#7,729,343
of 23,505,669 outputs
Outputs from BMC Neuroscience
#383
of 1,262 outputs
Outputs of similar age
#40,917
of 157,019 outputs
Outputs of similar age from BMC Neuroscience
#5
of 9 outputs
Altmetric has tracked 23,505,669 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,262 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,019 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.