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Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology

Overview of attention for article published in Journal of Hematology & Oncology, October 2010
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Title
Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
Published in
Journal of Hematology & Oncology, October 2010
DOI 10.1186/1756-8722-3-38
Pubmed ID
Authors

Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial, Aldo M Roccaro

Abstract

Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences support the hypothesis that epigenetic modifications lead to Waldesntrom cell proliferation and therefore play a crucial role in the pathogenesis of this disease. Indeed, while cytogenetic and gene expression analysis have demonstrated minimal changes; microRNA aberrations and modification in the histone acetylation status of primary Waldenstrom Macroglobulinemia tumor cells have been described. These findings provide a better understanding of the underlying molecular changes that lead to the initiation and progression of this disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 34%
Other 7 22%
Student > Ph. D. Student 4 13%
Student > Master 4 13%
Professor 1 3%
Other 1 3%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 31%
Medicine and Dentistry 6 19%
Biochemistry, Genetics and Molecular Biology 5 16%
Chemistry 3 9%
Nursing and Health Professions 1 3%
Other 2 6%
Unknown 5 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2011.
All research outputs
#7,453,350
of 22,786,087 outputs
Outputs from Journal of Hematology & Oncology
#499
of 1,190 outputs
Outputs of similar age
#35,200
of 99,242 outputs
Outputs of similar age from Journal of Hematology & Oncology
#2
of 3 outputs
Altmetric has tracked 22,786,087 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,190 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 99,242 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.