Title |
Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
|
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Published in |
Journal of Hematology & Oncology, October 2010
|
DOI | 10.1186/1756-8722-3-38 |
Pubmed ID | |
Authors |
Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial, Aldo M Roccaro |
Abstract |
Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences support the hypothesis that epigenetic modifications lead to Waldesntrom cell proliferation and therefore play a crucial role in the pathogenesis of this disease. Indeed, while cytogenetic and gene expression analysis have demonstrated minimal changes; microRNA aberrations and modification in the histone acetylation status of primary Waldenstrom Macroglobulinemia tumor cells have been described. These findings provide a better understanding of the underlying molecular changes that lead to the initiation and progression of this disease. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 34% |
Other | 7 | 22% |
Student > Ph. D. Student | 4 | 13% |
Student > Master | 4 | 13% |
Professor | 1 | 3% |
Other | 1 | 3% |
Unknown | 4 | 13% |
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Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
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