Title |
GPX-Macrophage Expression Atlas: A database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults
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Published in |
BMC Genomics, December 2005
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DOI | 10.1186/1471-2164-6-178 |
Pubmed ID | |
Authors |
Graeme R Grimes, Stuart Moodie, John S Beattie, Marie Craigon, Paul Dickinson, Thorsten Forster, Andrew D Livingston, Muriel Mewissen, Kevin A Robertson, Alan J Ross, Garwin Sing, Peter Ghazal |
Abstract |
Macrophages play an integral role in the host immune system, bridging innate and adaptive immunity. As such, they are finely attuned to extracellular and intracellular stimuli and respond by rapidly initiating multiple signalling cascades with diverse effector functions. The macrophage cell is therefore an experimentally and clinically amenable biological system for the mapping of biological pathways. The goal of the macrophage expression atlas is to systematically investigate the pathway biology and interaction network of macrophages challenged with a variety of insults, in particular via infection and activation with key inflammatory mediators. As an important first step towards this we present a single searchable database resource containing high-throughput macrophage gene expression studies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 9% |
Unknown | 30 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 33% |
Student > Ph. D. Student | 5 | 15% |
Student > Master | 5 | 15% |
Professor | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 6 | 18% |
Unknown | 1 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 48% |
Biochemistry, Genetics and Molecular Biology | 6 | 18% |
Medicine and Dentistry | 5 | 15% |
Psychology | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Other | 1 | 3% |
Unknown | 2 | 6% |