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Mendeley readers
Attention Score in Context
| Title |
Deubiquitylating enzymes and disease
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, October 2008
|
| DOI | 10.1186/1471-2091-9-s1-s3 |
| Pubmed ID | |
| Authors |
Shweta Singhal, Matthew C Taylor, Rohan T Baker |
| Abstract |
Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate any UBIQ-mediated cellular process, the two best characterized being proteolysis and protein trafficking. Mammals contain some 80-90 DUBs in five different subfamilies, only a handful of which have been characterized with respect to the proteins that they interact with and deubiquitylate. Several other DUBs have been implicated in various disease processes in which they are changed by mutation, have altered expression levels, and/or form part of regulatory complexes. Specific examples of DUB involvement in various diseases are presented. While no specific drugs targeting DUBs have yet been described, sufficient functional and structural information has accumulated in some cases to allow their rapid development. PUBLICATION HISTORY : Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com). |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| United Kingdom | 2 | 2% |
| United States | 2 | 2% |
| India | 1 | 1% |
| Canada | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 82 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 31% |
| Researcher | 19 | 21% |
| Student > Master | 13 | 14% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 5 | 5% |
| Other | 12 | 13% |
| Unknown | 7 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 53% |
| Biochemistry, Genetics and Molecular Biology | 18 | 20% |
| Chemistry | 10 | 11% |
| Medicine and Dentistry | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 8 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2021.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#36,800
of 102,854 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#7
of 28 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,854 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.