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A feasible strategy for preventing blood clots in critically ill patients with acute kidney injury (FBI): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, June 2014
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Title
A feasible strategy for preventing blood clots in critically ill patients with acute kidney injury (FBI): study protocol for a randomized controlled trial
Published in
Trials, June 2014
DOI 10.1186/1745-6215-15-226
Pubmed ID
Authors

Sian Robinson, Aleksander Zincuk, Ulla Lei Larsen, Claus Ekstrøm, Palle Toft

Abstract

Previous pharmacokinetic trials suggested that 40 mg subcutaneous enoxaparin once daily provided inadequate thromboprophylaxis for intensive care unit patients. Critically ill patients with acute kidney injury are at increased risk of venous thromboembolism and yet are often excluded from these trials. We hypothesized that for critically ill patients with acute kidney injury receiving continuous renal replacement therapy, a dose of 1 mg/kg enoxaparin subcutaneously once daily would improve thromboprophylaxis without increasing the risk of bleeding. In addition, we seek to utilize urine output prior to discontinuing dialysis, and low neutrophil gelatinase-associated lipocalin in dialysis-free intervals, as markers of renal recovery.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 1%
Canada 1 1%
Unknown 86 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 16%
Student > Postgraduate 11 13%
Student > Bachelor 11 13%
Student > Ph. D. Student 11 13%
Other 8 9%
Other 15 17%
Unknown 18 20%
Readers by discipline Count As %
Medicine and Dentistry 41 47%
Nursing and Health Professions 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Engineering 5 6%
Biochemistry, Genetics and Molecular Biology 2 2%
Other 6 7%
Unknown 22 25%