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Mendeley readers
| Title |
The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia
|
|---|---|
| Published in |
Journal of Neuroinflammation, February 2018
|
| DOI | 10.1186/s12974-018-1079-7 |
| Pubmed ID | |
| Authors |
Jada Bittle, Hanna E. Stevens |
| Abstract |
Maternal stress during pregnancy is associated with an increased risk of psychopathology in offspring. Resident immune cells of the brain, microglia, may be mediators of prenatal stress and altered neurodevelopment. Here, we demonstrate that neither the exogenous pro-inflammatory cytokine, interleukin-1β (IL-1β), nor the glucocorticoid hormone, corticosterone, recapitulated the full effects of prenatal stress on the morphology of microglial cells in the cortical plate of embryonic mice; IL-1β effects showed greater similarity to prenatal stress effects on microglia. Unexpectedly, oil vehicle alone, which has antioxidant properties, moderated the effects of prenatal stress on microglia. Microglia changes with prenatal stress were also sensitive to the antioxidant, N-acetylcysteine, suggesting redox dysregulation as a mechanism of prenatal stress. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 20% |
| Student > Bachelor | 7 | 18% |
| Student > Master | 7 | 18% |
| Student > Doctoral Student | 5 | 13% |
| Professor > Associate Professor | 4 | 10% |
| Other | 4 | 10% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 20% |
| Neuroscience | 7 | 18% |
| Agricultural and Biological Sciences | 6 | 15% |
| Psychology | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Other | 6 | 15% |
| Unknown | 6 | 15% |