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A role for cryptochromesin sleep regulation

Overview of attention for article published in BMC Neuroscience, December 2002
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  • Good Attention Score compared to outputs of the same age (76th percentile)

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1 X user
2 patents


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183 Mendeley
1 CiteULike
1 Connotea
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A role for cryptochromesin sleep regulation
Published in
BMC Neuroscience, December 2002
DOI 10.1186/1471-2202-3-20
Pubmed ID

Jonathan P Wisor, Bruce F O'Hara, Akira Terao, Chris P Selby, Thomas S Kilduff, Aziz Sancar, Dale M Edgar, Paul Franken


The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack circadian rhythms. We studied sleep in cry1,2-/- mice under baseline conditions as well as under conditions of constant darkness and enforced wakefulness to determine whether cryptochromes influence sleep regulatory processes. Under all three conditions, cry1,2-/- mice exhibit the hallmarks of high non-REM sleep (NREMS) drive (i.e., increases in NREMS time, NREMS consolidation, and EEG delta power during NREMS). This unexpected phenotype was associated with elevated brain mRNA levels of period 1 and 2 (per1,2), and albumin d-binding protein (dbp), which are known to be transcriptionally inhibited by CRY1,2. To further examine the relationship between circadian genes and sleep homeostasis, we examined wild type mice and rats following sleep deprivation and found increased levels of per1,2 mRNA and decreased levels of dbp mRNA specifically in the cerebral cortex; these changes subsided with recovery sleep. The expression of per3, cry1,2, clock, npas2, bmal1, and casein-kinase-1epsilon did not change with sleep deprivation. These results indicate that mice lacking cryptochromes are not simply a genetic model of circadian arrhythmicity in rodents and functionally implicate cryptochromes in the homeostatic regulation of sleep.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 3 2%
Germany 2 1%
Canada 2 1%
Austria 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
France 1 <1%
Israel 1 <1%
United States 1 <1%
Other 0 0%
Unknown 170 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 20%
Researcher 37 20%
Student > Bachelor 24 13%
Professor > Associate Professor 18 10%
Professor 17 9%
Other 33 18%
Unknown 17 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 59 32%
Neuroscience 27 15%
Medicine and Dentistry 23 13%
Biochemistry, Genetics and Molecular Biology 21 11%
Psychology 9 5%
Other 18 10%
Unknown 26 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2018.
All research outputs
of 25,394,764 outputs
Outputs from BMC Neuroscience
of 1,294 outputs
Outputs of similar age
of 136,282 outputs
Outputs of similar age from BMC Neuroscience
of 3 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,294 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them