Title |
Acetaminophen poisoning: an update for the intensivist
|
---|---|
Published in |
Critical Care, March 2002
|
DOI | 10.1186/cc1465 |
Pubmed ID | |
Authors |
Paul I Dargan, Alison L Jones |
Abstract |
Acetaminophen overdose is common and can result from deliberate/nonstaggered or accidental/staggered ingestion. Patients presenting within 24 h of an acetaminophen overdose can safely be managed on medical wards. Early management of nonstaggered overdose is guided by the plasma acetaminophen concentration, whereas management of accidental/staggered ingestion is guided by ingested dose. Ingested dose and time from ingestion to presentation are important prognostic factors in accidental/staggered ingestion. Acetaminophen-induced acute liver failure (ALF) requires meticulous supportive care in an intensive care unit (ICU), with early identification and transfer of patients who are likely to require liver transplantation to a specialist liver centre. The modified King's College Hospital criteria (incorporating lactate into the traditional criteria) represent the best tool for identifying patients who require transplantation. |
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Geographical breakdown
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India | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
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Other | 15 | 23% |
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Other | 16 | 25% |
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Immunology and Microbiology | 2 | 3% |
Other | 0 | 0% |
Unknown | 10 | 16% |