Title |
Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype and SAA1 and MICA polymorphisms effects
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Published in |
BMC Medical Genomics, February 2004
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DOI | 10.1186/1471-2350-5-4 |
Pubmed ID | |
Authors |
Myrna Medlej-Hashim, Valérie Delague, Eliane Chouery, Nabiha Salem, Mohammed Rawashdeh, Gérard Lefranc, Jacques Loiselet, André Mégarbané |
Abstract |
Familial mediterranean fever (FMF) is a recessively inherited disease characterized by recurrent crises of fever, abdominal, articular and/or thoracic pain. The most severe complication is the development of renal amyloidosis. Over 35 mutations have been discovered so far in the gene responsible for the disease, MEFV. This article aims at determining a correlation between the MEFV genotype and the occurrence of amyloidosis in FMF patients, in addition to the study of the modifying effects of the SAA1 (type 1 serum amyloid A protein) and MICA (Major Histocompatibility Complex (MHC) class-I-chain-related gene A) genes on this severe complication. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 80% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 23% |
Researcher | 5 | 11% |
Student > Master | 5 | 11% |
Student > Bachelor | 4 | 9% |
Other | 3 | 7% |
Other | 8 | 18% |
Unknown | 9 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 45% |
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Agricultural and Biological Sciences | 6 | 14% |
Unknown | 9 | 20% |