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Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota

Overview of attention for article published in BMC Veterinary Research, February 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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Title
Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota
Published in
BMC Veterinary Research, February 2018
DOI 10.1186/s12917-018-1370-y
Pubmed ID
Authors

Giovanni Widmer, Lluís Ferrer, Claude Favrot, Judy Paps, Kevin Huynh, Thierry Olivry

Abstract

As prednisone and ciclosporin can have immunosuppressive effects and have been considered potential predisposing factors for skin infections, we investigated the impact of these drugs on the diversity of the cutaneous microbiota, the abundance of Malassezia and infection with Papillomaviruses. Six atopic, asymptomatic Maltese-beagle dogs were treated with ciclosporin for one month and then with prednisone for another month, with a one-month wash-out between treatments. The dogs were sampled on the abdomen and pinna before and after each treatment using a swab. Samples for Papillomavirus detection were obtained with cytobrush sticks. The bacterial microbiota was characterized using 16S amplicon high-throughput sequencing. Malassezia populations were quantified with nested real-time PCR targeting the ribosomal internal transcribed spacer 1. The diversity and composition of cutaneous microbiota was not impacted in a detectable manner by any of the treatments. As observed for the bacterial microbiota, Malassezia populations were not affected by treatment. Three dogs were positive for Papillomavirus at more than one timepoint, but an association with treatment was not apparent. Ciclosporin and prednisone at doses used for the treatment of atopic dermatitis do not impact the canine cutaneous microbiota in a detectable manner.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 10 15%
Researcher 8 12%
Other 7 11%
Student > Bachelor 5 8%
Student > Ph. D. Student 5 8%
Other 10 15%
Unknown 20 31%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 26 40%
Medicine and Dentistry 6 9%
Agricultural and Biological Sciences 6 9%
Immunology and Microbiology 4 6%
Engineering 2 3%
Other 1 2%
Unknown 20 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2018.
All research outputs
#3,296,621
of 23,025,074 outputs
Outputs from BMC Veterinary Research
#235
of 3,067 outputs
Outputs of similar age
#69,668
of 330,325 outputs
Outputs of similar age from BMC Veterinary Research
#7
of 103 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,067 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,325 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.