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Mendeley readers
Attention Score in Context
| Title |
HIV-1 Vif and APOBEC3G: Multiple roads to one goal
|
|---|---|
| Published in |
Retrovirology, September 2004
|
| DOI | 10.1186/1742-4690-1-28 |
| Pubmed ID | |
| Authors |
Joao Goncalves, Mariana Santa-Marta |
| Abstract |
The viral infectivity factor, Vif, of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of non-permissive cells, like peripheral blood mononuclear cells (PBMC). Vif functions to counteract an anti-retroviral cellular factor in non-permissive cells named APOBEC3G. The current mechanism proposed for protection of the virus by HIV-1 Vif is to induce APOBEC3G degradation through a ubiquitination-dependent proteasomal pathway. However, a new study published in Retrovirology by Strebel and colleagues suggests that Vif-induced APOBEC3G destruction may not be required for Vif's virus-protective effect. Strebel and co-workers show that Vif and APOBEC3G can stably co-exist, and yet viruses produced under such conditions are fully infectious. This new result highlights the notion that depletion of APOBEC3G is not the sole protective mechanism of Vif and that additional mechanisms exerted by this protein can be envisioned which counteract APOBEC3G and enhance HIV infectivity. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Portugal | 1 | 1% |
| Unknown | 63 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 29% |
| Researcher | 13 | 19% |
| Student > Bachelor | 7 | 10% |
| Professor > Associate Professor | 6 | 9% |
| Student > Master | 6 | 9% |
| Other | 11 | 16% |
| Unknown | 5 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 35% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Medicine and Dentistry | 8 | 12% |
| Chemistry | 7 | 10% |
| Immunology and Microbiology | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 7 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2021.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Retrovirology
#455
of 1,273 outputs
Outputs of similar age
#24,085
of 73,434 outputs
Outputs of similar age from Retrovirology
#5
of 9 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,434 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.