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X Demographics
Mendeley readers
Attention Score in Context
| Title |
i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases
|
|---|---|
| Published in |
Genome Biology, February 2018
|
| DOI | 10.1186/s13059-018-1400-x |
| Pubmed ID | |
| Authors |
Masato Ohtsuka, Masahiro Sato, Hiromi Miura, Shuji Takabayashi, Makoto Matsuyama, Takayuki Koyano, Naomi Arifin, Shingo Nakamura, Kenta Wada, Channabasavaiah B. Gurumurthy |
| Abstract |
We present a robust method called improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) that delivers CRISPR ribonucleoproteins to E0.7 embryos via in situ electroporation. The method generates mouse models containing single-base changes, kilobase-sized deletions, and knock-ins. The efficiency of i-GONAD is comparable to that of traditional microinjection methods, which rely on ex vivo handling of zygotes and require recipient animals for embryo transfer. In contrast, i-GONAD avoids these technically difficult steps, and it can be performed at any laboratory with simple equipment and technical expertise. Further, i-GONAD-treated females retain reproductive function, suggesting future use of the method for germline gene therapy. |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 20% |
| Japan | 7 | 11% |
| United Kingdom | 6 | 9% |
| Spain | 4 | 6% |
| United Arab Emirates | 1 | 2% |
| Australia | 1 | 2% |
| Estonia | 1 | 2% |
| China | 1 | 2% |
| Netherlands | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 27 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 57% |
| Scientists | 19 | 29% |
| Science communicators (journalists, bloggers, editors) | 5 | 8% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 275 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 275 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 62 | 23% |
| Student > Ph. D. Student | 50 | 18% |
| Student > Bachelor | 25 | 9% |
| Student > Master | 20 | 7% |
| Professor > Associate Professor | 15 | 5% |
| Other | 40 | 15% |
| Unknown | 63 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 81 | 29% |
| Agricultural and Biological Sciences | 58 | 21% |
| Neuroscience | 20 | 7% |
| Medicine and Dentistry | 19 | 7% |
| Immunology and Microbiology | 5 | 2% |
| Other | 22 | 8% |
| Unknown | 70 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2021.
All research outputs
#755,127
of 25,836,587 outputs
Outputs from Genome Biology
#482
of 4,523 outputs
Outputs of similar age
#16,901
of 345,147 outputs
Outputs of similar age from Genome Biology
#8
of 49 outputs
Altmetric has tracked 25,836,587 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,523 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.