Title |
Modeling metabolic networks in C. glutamicum: a comparison of rate laws in combination with various parameter optimization strategies
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Published in |
BMC Systems Biology, January 2009
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DOI | 10.1186/1752-0509-3-5 |
Pubmed ID | |
Authors |
Andreas Dräger, Marcel Kronfeld, Michael J Ziller, Jochen Supper, Hannes Planatscher, Jørgen B Magnus, Marco Oldiges, Oliver Kohlbacher, Andreas Zell |
Abstract |
To understand the dynamic behavior of cellular systems, mathematical modeling is often necessary and comprises three steps: (1) experimental measurement of participating molecules, (2) assignment of rate laws to each reaction, and (3) parameter calibration with respect to the measurements. In each of these steps the modeler is confronted with a plethora of alternative approaches, e. g., the selection of approximative rate laws in step two as specific equations are often unknown, or the choice of an estimation procedure with its specific settings in step three. This overall process with its numerous choices and the mutual influence between them makes it hard to single out the best modeling approach for a given problem. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 4 | 4% |
Portugal | 1 | <1% |
Malaysia | 1 | <1% |
Czechia | 1 | <1% |
United Kingdom | 1 | <1% |
Taiwan | 1 | <1% |
Denmark | 1 | <1% |
China | 1 | <1% |
Spain | 1 | <1% |
Other | 1 | <1% |
Unknown | 97 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 27% |
Researcher | 28 | 25% |
Student > Master | 13 | 12% |
Professor | 7 | 6% |
Student > Doctoral Student | 6 | 5% |
Other | 15 | 14% |
Unknown | 11 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 38% |
Biochemistry, Genetics and Molecular Biology | 16 | 15% |
Computer Science | 16 | 15% |
Engineering | 10 | 9% |
Chemistry | 2 | 2% |
Other | 12 | 11% |
Unknown | 12 | 11% |