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Mendeley readers
Attention Score in Context
| Title |
Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer
|
|---|---|
| Published in |
Breast Cancer Research, June 2000
|
| DOI | 10.1186/bcr50 |
| Pubmed ID | |
| Authors |
Xihong Zhang, Douglas Yee |
| Abstract |
The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Norway | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 26% |
| Researcher | 8 | 17% |
| Professor > Associate Professor | 5 | 11% |
| Student > Bachelor | 4 | 9% |
| Student > Doctoral Student | 4 | 9% |
| Other | 7 | 15% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 35% |
| Biochemistry, Genetics and Molecular Biology | 7 | 15% |
| Medicine and Dentistry | 7 | 15% |
| Chemistry | 3 | 7% |
| Nursing and Health Professions | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 7 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2019.
All research outputs
#4,814,550
of 23,237,082 outputs
Outputs from Breast Cancer Research
#590
of 1,920 outputs
Outputs of similar age
#5,936
of 39,453 outputs
Outputs of similar age from Breast Cancer Research
#1
of 2 outputs
Altmetric has tracked 23,237,082 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,920 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them